United States securities and exchange commission logo

                              July 1, 2020

       James McCullough
       Chief Executive Officer
       Renalytix AI plc
       Avon House 19 Stanwell Road
       Penarth, Cardiff CF64 2EZ
       United Kingdom

                                                        Re: Renalytix AI plc
Statement on Form F-1
                                                            Filed June 24, 2020
                                                            File No. 333-239414

       Dear Mr. McCullough:

               We have reviewed your registration statement and have the
following comment. Please
       respond to this letter by amending your registration statement and
providing the requested
       information. If you do not believe our comment applies to your facts and
circumstances or do
       not believe an amendment is appropriate, please tell us why in your

              After reviewing any amendment to your registration statement and
the information you
       provide in response to this comment, we may have additional comments.

       Registration Statement on Form F-1, filed on June 24, 2020

       Note 11, Subsequent Events, Verici Dx Limited, page F-41

                                                        With respect to the
spin-off of Verici Dx Limited, please provide pro forma statements
                                                        reflecting the
disposition under Article 11 of Regulation S-X, or tell us why you are not
                                                        required to provide the
statements. Refer to Item 4(b) of Form F-1.

               We remind you that the company and its management are
responsible for the accuracy
       and adequacy of their disclosures, notwithstanding any review, comments,
action or absence of
       action by the staff.

              Refer to Rules 460 and 461 regarding requests for acceleration.
Please allow adequate
       time for us to review any amendment prior to the requested effective
date of the registration
 James McCullough
Renalytix AI plc
July 1, 2020
Page 2

       You may contact Jeanne Bennett at 202-551-3606 or Kate Tillan at
202-551-3604 if you
have questions regarding comments on the financial statements and related
matters. Please
contact Paul Fischer at 202-551-3415 or Celeste M. Murphy at 202-551-3257 with
any other

FirstName LastNameJames McCullough
                                                         Division of
Corporation Finance
Comapany NameRenalytix AI plc
                                                         Office of Life
July 1, 2020 Page 2
cc:       Alison Haggerty, Esq.
FirstName LastName