KidneyIntelX in Multi-Center Study
("RenalytixAI", the "Company")
KidneyIntelX in Multi-Center Study to Monitor and Predict Kidney Risk in COVID-19 Patients
Surge in Chronic Kidney Disease and Kidney Failure Expected Post-COVID-19
Mount Sinai-Led Study to Assess 4,000 Surviving COVID-19 Patients
The study, titled "Multi-center Assessment of Survivors for Kidney Disease after COVID-19 (MASKeD-COVID)," expands on the Pred-MAKER study previously announced
KidneyIntelX will be used to assess risk for new chronic kidney disease (CKD) in the short-term or kidney disease progression over the longer-term in patients who have recovered from COVID-19. Diverse data inputs, including validated blood and urine-based biomarkers, inherited genetics and extensive patient data from electronic health record systems, will be incorporated into the KidneyIntelX machine learning-enabled algorithm to generate a unique patient risk score. In addition,
"With the pandemic spread of COVID-19 and the increased morbidity and mortality from COVID-19 in patients with diabetes, CKD and acute kidney injury, it is imperative to define the underlying mechanisms of COVID-associated kidney disease and develop solutions to guide patient care," said
"This collaborative approach is vital for us to further develop some important findings by the respective groups to date," said
SARS-CoV-2 is believed to result in acute kidney injury through multiple mechanisms, including severe inflammation, endothelial damage, microthrombi, and possibly direct invasion of the virus into kidney epithelial cells.3 The burden and incidence of post-COVID-19 CKD and end-stage kidney disease (ESKD) is currently unknown, given the recency of the pandemic. However, emerging evidence suggests patients surviving COVID-19 will experience a significant increased risk of kidney disease, including the following:
· Approximately 20% to 45% of patients hospitalized with COVID-19 in
· Data from an analysis of over 3,000 patients admitted to Mount Sinai indicates that 50% of surviving patients who experienced AKI during hospitalization for COVID-19 had persistently abnormal kidney function at the time of discharge;5
· It has been established in the literature that AKI is strongly associated with development of CKD, CKD progression, and ESKD;6
· Given the observed severity of kidney injury in many COVID-19 patients, both clinically and histopathologically, the risk for subsequent transition to CKD and ESKD is likely to be high in survivors.7
"There are so many questions yet to be answered regarding COVID-19 and kidney disease. For example, we don't yet know the risk factor and mediators of AKI to CKD transition after COVID-19. We also don't know the predictors of long-term outcomes after COVID-19," said Evren Azeloglu, Ph.D., Assistant Professor of Nephrology and Pharmacological Sciences at the
The MASKeD-COVID study will be coordinated by Mount Sinai, which has already implemented a
About the
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For further information, please contact:
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Via Walbrook PR |
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Stifel (Nominated Adviser, Joint Broker) |
Tel: 020 7710 7600 |
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N+1 Singer (Joint Broker) |
Tel: 020 7496 3000 |
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Tel: 020 7933 8780 or renalytix@walbrookpr.com |
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Mob: 07980 541 893 / 07584 391 303 |
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About RenalytixAI
RenalytixAI is a commercial-stage artificial intelligence-enabled in vitro diagnostics company, focused on optimizing clinical management in CKD to help drive improved patient outcomes and significantly lower healthcare costs. KidneyIntelX, our first-in-class diagnostic platform, employs a proprietary artificial intelligence-enabled algorithm that combines diverse data inputs, including validated blood-based biomarkers, inherited genetics and extensive personalized patient data from electronic health record, or EHR, systems to generate a unique patient risk score. KidneyIntelX is based on technology developed by Mount Sinai faculty and licensed to RenalytixAI. Mount Sinai and
Notes:
1 https://covidtracking.com/data/download
2 https://www.medrxiv.org/content/10.1101/2020.05.09.20096511v1
3, 4 http://www.nephjc.com/news/covidaki
5 https://www.medrxiv.org/content/10.1101/2020.05.04.20090944v1
6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788581/
7 https://jasn.asnjournals.org/content/31/7/1380
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This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are statements that are not historical facts, and in some cases can be identified by terms such as "may," "will," "could," "expects," "plans," "anticipates," and "believes." These statements include, but are not limited to, statements regarding the conduct, design and timing of the MASKeD-COVID clinical trial, including the timing of initial research findings and the timing and viability of commercialization of KidneyIntelX in the COVID-19 population, as well as the participation of other institutions in the MASKeD-COVID clinical trial and the potential benefits of KidneyIntelX in assessing kidney disease in the context of COVID-19. Any forward-looking statements are based on management's current views and assumptions and involve risks and uncertainties that could cause actual results, performance or events to differ materially from those expressed or implied in such statements. We may not actually achieve the plans and objectives disclosed in the forward-looking statements, and you should not place undue reliance on our forward-looking statements. Various important factors could cause actual results or events to differ materially from those that may be expressed or implied by our forward-looking statements, including those described in the "Risk Factors" section of our final prospectus filed with the
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